Microcrystalline Cellulose (MCC) Manufacturing Industry. Production of Pharmaceutical Grade Microcrystalline Cellulose

Microcrystalline Cellulose Market Projected to Reach 1540 Million US$ by 2025, at a CAGR of 6.3%

Microcrystalline cellulose (C6H10O5)n is refined wood pulp. It is a white, free-flowing powder. Chemically, it is an inert substance, is not degraded during digestion and has no appreciable absorption. In large quantities it provides dietary bulk and may lead to a laxative effect.

Microcrystalline Cellulose (MCC) is a partially depolymerized specialty cellulose prepared by treating α-cellulose. MCC is widely used in pharmaceutical, food & beverage, cosmetic and other industrial applications, owing to its broad spectrum of properties. MCC is used a suspension stabilizer and an excipient, owing to its chemical inertness and non-toxic nature.

Microcrystalline cellulose (MCC) is a free-flowing crystalline powder (a non-fibrous microparticle). It is insoluble in water, dilute acids and most organic solvents, but slightly soluble in the alkali solution of 20%. It has a wide range of uses in the pharmaceutical excipients and can be directly used for tabletting of dry powder. It is widely used as pharmaceutical excipients, flow aids, fillers, disintegrating agents, anti-sticking agents, adsorbents, and capsule diluents.

Microcrystalline cellulose is widely used in pharmaceuticals, primarily as a binder/diluent in oral tablet and capsule formulations where it is used in both wet-granulation and direct-compression processes.

In addition, wide ranges of chemical, technical, and economic merits are attached with its utilization. It has found its applications in the cosmetics & personal care industry, as well as in the food sector. When it comes to food production, it acts as an anti-caking agent, a fat substitute, an emulsifier, an extender, as well as a bulking agent.

And as far as the beverage sector is concerned, it acts as a gelling agent, stabilizer, anti-caking agents and suspending agents. It is widely employed as a fat substitute, thickener, binder in cosmetics industry. Besides all that, it has applications in the pharmaceutical industry as it displays chemical inertness and deficiency of taste and aroma. As an excipient, it is utilized in almost every type of oral dosage entailing pellets, tablets, capsules, sachets, and others.

Market Outlook

The MCC market is projected to grow from USD 885.1 million in 2018 to USD 1,241.4 million by 2023, at a CAGR of 7.0% between 2018 and 2023.

Microcrystalline cellulose is a partially depolymerized cellulose in pure form, which is synthesized from -cellulose precursor. There are several ways to synthesize microcrystalline cellulose such as reactive extrusion, acid hydrolysis, steam explosion and enzyme mediated synthesis. Microcrystalline cellulose has large scale applications in the pharmaceutical, food & beverage, and personal care industries. In the food & beverage industry, microcrystalline cellulose is added to the processed food to create a creamy and smooth mouth feel. This is mostly used to prepare low-fat dairy products such as frozen yogurt, whipped cream, and ice cream. In the pharmaceutical industry, it is used as fillers, disintegrating agents, anti-sticking agents, adsorbents, and capsule diluents.

Increasing application of microcrystalline cellulose in various industries is a major factor propelling growth of the global microcrystalline cellulose market. For instance, microcrystalline cellulose is used as stabilizer, gelling agent, suspending agent, and anti-caking agent in beverages. It is also used as a cold and hot stabilizer, in frozen food, ice cream, and canned meat, in order to improve the shelf life of the product. Furthermore, MCC (Microcrystalline Cellulose) is widely used in pharmaceuticals, owing to its tasteless, odor less, and chemical inertness properties. The steadily growing pharmaceutical industry is expected to support the market growth of microcrystalline cellulose over the forecast period. However, high production cost along with low production yield are major factors hampering growth of the market.

Rapid growth in the food & beverage industry and increasing demand for low-fat processed food is expected to favor the market growth during the forecast period. The rising demand for the low-fat packaged food products in developing economies due to the globalization and health-conscious consumers has fuelled the market growth. Packaged and processed food products need to be kept fresh for a longer period, for which the bulking, texturizing, and the anti-caking agents are required. These properties of microcrystalline cellulose are the key drivers of the market growth.

MCC acts as a filler, binder, disintegrant, suspending agent, lubricant, and glidant in pharmaceutical manufacturing. It is used in the direct compression method as it reduces the production cost. MCC is a vital component that is used in every form of oral dosage, which includes pellets, capsules, tablets, sachets, and others.

Some of the key players operating in the MCC market are Mingtai Chemical Co., Ltd., Asahi Kasei Corporation, J. Rettenmaier & Söhne GmbH + Co KG, Blanver Farmoquímica LTDA, Accent Microcell Pvt. Ltd., FMC Corporation, Juku Orchem Private Limited, DFE Pharma GmbH & Co. KG, Libraw Pharma, Sigachi Industrial Pvt. Ltd., and Avantor Performance Materials, Inc.

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